The McMaster University Medical Centre is home to an 11 MeV Siemens RDS-112 negative ion cyclotron designed for the production of short-lived positron-emitting isotopes such as F-18, C-11 and N-13. Operation of the cyclotron is currently overseen by the Center for Probe Development and Commercialization. At the present time, the cyclotron is primarily used for the production of fluorine-18 which is then incorporated into the radiopharmaceutical [F-18]-FDG (fluorodeoxyglucose) using automated synthesis protocols. The [F-18]-F18FDGFDG is used in the clinic for imaging various disease states by Positron Emission Tomography (PET). Cyclotron-produced F-18 is also utilized for research purposes, particularly the development of novel molecular imaging agents. For more information, please contact the CPDC.

A recent (2009) Knowledge Infrastructure Program grant to McMaster University has allowed for the purchase of a new GE PETtrace cyclotron, which was installed in the Spring of 2011. The 10-ton, $2-million cyclotron is housed in the Tandem Accelerator Building adjacent to a suite of hot cells and a “clean room” facility dedicated to the production and quality assurance of sterile, clinical grade radiopharmaceuticals. For further information about this cyclotron, contact Scott McMaster.

Cyclotron

The new GE PETtrace cyclotron installed in 2011.